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MOTs-C

TRANSFORM WITH

MOTs-C

MOTS-c is a mitochondrial peptide that boosts metabolism by activating AMPK in muscle, improving insulin sensitivity, enhancing glucose and fat burning, and helping prevent obesity and age-related metabolic issues.

✓
Helps burn fat
✓
Improves muscle efficiency
✓
Can help protect against aging
✓
Receive your medication in as little as 7 days**

from $249/mo.*

*with Membership, consult, and provider approval

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PROVIDER-SUPPORTED PROGRAMS
MEDICATION SHIPPED DISCREETLY TO YOUR DOOR
1:1 DOCTOR-LED CARE, EVERY QUARTER
ALL NECESSARY SUPPLIES ALWAYS FREE
BEST MEDICATION PRICES

The science behind
MOTs-C

MOTS-c is a small peptide produced inside our mitochondria that acts like a natural booster for metabolism. It works mainly by activating AMPK - a key energy sensor in skeletal muscle, which helps the body use glucose and fats more efficiently for fuel. This leads to better insulin sensitivity, faster burning of stored fat, less fat buildup, and protection against weight gain from poor diet or aging. Overall, MOTS-c supports healthier metabolic balance and may help prevent or improve conditions like insulin resistance, obesity, and age-related metabolic slowdown.
Science behind MOTs-C

The mechanism of
MOTs-C

MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded by the mitochondrial genome that translocates to the nucleus under metabolic stress to regulate adaptive gene expression. Its primary target is skeletal muscle, where it inhibits the folate cycle and de novo purine biosynthesis, leading to accumulation of AICAR and subsequent activation of AMPK (AMP-activated protein kinase), a central regulator of cellular energy homeostasis. This pathway enhances insulin sensitivity, promotes glucose uptake and utilization, stimulates fatty acid β-oxidation, increases energy expenditure, and attenuates fat accumulation, thereby helping to prevent high-fat diet-induced obesity, age-related insulin resistance, and associated metabolic dysregulation in preclinical models, while also supporting mitochondrial function, proteostasis, and stress adaptation without direct hormonal interference.
INGREDIENTS
MOTs-C Peptide
BENEFITS
MOTS-c offers several key benefits for metabolic health and anti-aging: it improves insulin sensitivity and glucose regulation to help control blood sugar, enhances fat burning and reduces fat accumulation (especially visceral fat), boosts energy levels and physical performance by optimizing mitochondrial function, increases metabolic flexibility and energy expenditure, reduces inflammation, supports muscle health and endurance, and may help prevent or mitigate age-related issues like obesity, insulin resistance, and overall decline in metabolic efficiency—acting somewhat like an exercise mimetic at the cellular level.
  • ✔Improves muscle efficiency
  • ✔Promotes healthy cellular metabolism and fat burning
Doctors Say:
A physician might choose MOTS-c (a mitochondrial-derived peptide) over metformin (the standard first-line oral antidiabetic drug) for supporting metabolic health, weight loss, and anti-aging in certain patients—particularly those with insulin resistance, obesity, or age-related metabolic decline—because MOTS-c acts primarily in skeletal muscle (the body's largest insulin-sensitive tissue) to activate the AMPK pathway more directly, mimicking exercise effects by enhancing glucose uptake, fatty acid oxidation, energy expenditure, and metabolic flexibility while preventing diet- and age-induced insulin resistance and fat accumulation in preclinical models. In contrast, metformin primarily targets the liver to reduce hepatic glucose production, with more modest direct effects on muscle, and it carries potential drawbacks like gastrointestinal side effects, risk of lactic acidosis (rare), possible blunting of exercise benefits in some studies, and hepatotoxicity concerns in certain contexts. MOTS-c is positioned as a more "natural" mitochondrial signal that may avoid these issues, promote restorative rather than suppressive metabolic changes, and offer broader anti-aging advantages like improved mitochondrial function and stress adaptation.
Profile
  • Once daily
  • Injectable
  • Varies on use and need
60%
more affordable than our competitors.
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NAD+Med / IV Clinics
25mg injection$59 per shot$7 per shot*
1000mg (40 treatments)$2,360$249 (supplies included)**
Private At-Home UseNoYes
US FDA-Inspected PharmacyNoYes
*with Membership
**1000mg vial (40 × 25mg injections)
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*Disclaimer: "TRT or B12 Included In Program - No Additional Charge!" requires provider approval before starting treatment. Labs are required to verify eligibility and are not included in the membership. Program includes Testosterone Cypionate up to 200mg per week AND anastrozole either as a Cyp/Anastrozole blend or as anastrozole as an adjunct therapy up to 10 capsules per month. Program also includes Enclomiphene (up to 50mg daily), Clomiphene (up to 50mg daily), or B12 (up to 1000mcg weekly) as an alternative to Testosterone therapy. Program does not include Testosterone AND Enclomiphene, Clomiphene, or B12 together if prescribed in conjunction. Program does not include testosterone blends such as testosterone cypionate/ethanate/proprionate, testosterone creams, or gonadotropins such as HCG or gonadorelin. Program does not include any other medication. This program is subject to change at any time.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate.